SLC22 family of organic cation and anion transporters in GtoPdb v.2023.1

The SLC22 family of transporters is mostly composed non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role drug disposition. may be divided into three subfamilies based on the nature substrate transported: organic cations (OCTs), anions (OATs) zwiterrion/cations (OCTN). Membrane topology predicted to contain 12 TM domains with intracellular termini, an extended extracellular loop at 1/2.